Clinical Note Generation: Claude Sonnet 4.6 vs GPT-5.4 mini at 100K-Token Scale

Claude Sonnet 4.6 vs GPT-5.4 mini
Complete Comparison: 100,000 input tokens × 2,000 output tokens
Comparison Mode
⚡ 50% Cached

Complete comparison of pricing, performance, and capabilities for 2 leading AI models with 50% Cached.

⚡ Caching Optimized (up to 90% savings) 📊 Batch API
Comparison Criteria Claude Sonnet 4.6
Anthropic
GPT-5.4 mini
OpenAI
Calculation Results (Current Inputs) (50% cached)
Input Tokens 100,000 100,000
Output Tokens 2,000 2,000
Cost Breakdown
Input Cost $0.075000 (rounded ~ $0.08)Worst $0.018750 (rounded ~ $0.02)Best
Output Cost $0.007500 (rounded ~ $0.01)Worst $0.002250Best
Unit Cost (Audio/OCR) $0.000000 $0.000000
Service Fees $0.000000 $0.000000
Total Cost $0.048750 (rounded ~ $0.05) Most Expensive $0.012563 (rounded ~ $0.01) Best Value
Processing Time 3 minutes, 51.38 seconds Slowest 3 minutes, 28.26 seconds Fastest
Tokens per Second 450Slowest 500Fastest
Time to First Token 200ms Worst 180ms Best
Cost per 1K tokens $0.000478Worst $0.000123Best
Tokens per Dollar 2,092,308Worst Value 8,119,403Best Value
Cost per 1 Million Tokens (Informational)
Input Cost / 1M (Base) $0.750000Worst $0.187500 (rounded ~ $0.19)Best
Output Cost / 1M (Base) $3.750000Worst $1.125000 (rounded ~ $1.13)Best
Input Cost / 1M (Optimized) $0.375000 (rounded ~ $0.38)Worst
Optimizations: 50.0% batch
$0.093750 (rounded ~ $0.09)Best
Optimizations: 50.0% batch
Output Cost / 1M (Optimized) $1.875000 (rounded ~ $1.88)Worst
Optimizations: 50.0% batch
$0.562500 (rounded ~ $0.56)Best
Optimizations: 50.0% batch
Capabilities & Advanced Features
Images Support ✓ Supported ✓ Supported
Caching Support
50
✓ Supported ✓ Supported
Batch API Support ✓ Supported ✓ Supported
Tool Usage Support ✓ Supported ✓ Supported
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Select AI Model

Claude Sonnet 4.6
AnthropicMax Context: 1,000,000 tokens
$3 / $15 per 1M tokens
▼
▼
Use Batch API (50% discount)
50%
Provider-specific multipliers applied after all calculations
Enable for cache discounts
Select platform to enforce context limits
Number of requests (max 1M). Summary view auto-enabled >10k.

Calculate Token Costs

$0.048750 Total Cost
$0.037500 Input Cost
$0.007500 Output Cost
$0.000000 Unit Cost
$0.000000 Search Cost
$0.000000 Request Fee
$0.000000 Tool Fee
$0.000000 Code Execution
102,000Total Tokens
$0.000478Cost per 1K
2,092,308Tokens per $
📊 Advanced Cost Breakdown

Processing Speed

3m 51s Processing Time
450 Tokens/Second
200ms Time to First Token
441 Effective Speed

Model Comparison

Select a model to see comparisons with competitors.

Model Information

Select a model to see detailed information.

🔄 Advanced Options

⚡ Optimization
Flat fee per session (e.g., $0.03 for Code Interpreter)
Hourly storage fee for cached data
First 50 hours free, $0.05/hour after
🧠 Reasoning & Thinking
Manual thinking tokens (billed at output rate)
🔧 Special Modes
Enable 6.0x Fast Mode multiplier
📚 Research & Citations
Enable $1.00/$4.00 rates + $10.00/1k search
Enable research tier pricing
Fee per source cited
🎤 Realtime Audio & Video
Session length for billing
📊 Multiple Models Detected: This page contains data for 2 models. See the detailed comparison table above, and switch between models using tabs below.

Claude Sonnet 4.6 Anthropic 1000000

$0.048750 (rounded ~ $0.05)
Total Cost
⚡ 50% Cached 📊 Batch API 🔧 Tools
👁️
Vision/Images
✓ Available
🎧
Audio Processing
✗ Not Available
🎥
Video Analysis
✗ Not Available
🔧
Tool Usage
✓ Available
📄
OCR Support
✗ Not Available
📊
Batch API
✓ Available
⚡
Caching
✓ Available
90% savings

💰 Total Cost Calculation (from Plugin)

Base Cost (No Optimizations) $0.082500 (rounded ~ $0.08) Input: $0.075000 (rounded ~ $0.08)
Output: $0.007500 (rounded ~ $0.01)
Optimized Cost $0.048750 (rounded ~ $0.05) Input: $0.075000 (rounded ~ $0.08)
Output: $0.007500 (rounded ~ $0.01)
Unit: $0.000000
Fees: $0.000000
Total Savings $0.033750 (rounded ~ $0.03) 40.9% discount

Advanced Cost Breakdown (from Plugin)

📊 Batch API
50.0% off
Asynchronous processing discount

Detailed Cost Analysis (from Plugin)

For 100,000 input tokens and 2,000 output tokens:

  • Input Cost: $0.075000 (rounded ~ $0.08)
  • Output Cost: $0.007500 (rounded ~ $0.01)
  • Total Cost: $0.048750 (rounded ~ $0.05)
  • Cost per 1K tokens: $0.000478
  • Tokens per dollar: 2,092,308 tokens
  • Context Window: 1000000 tokens

Speed & Performance Analysis

With a processing speed of 450 tokens per second and 200ms time to first token:

  • Processing Time: 3 minutes, 51.38 seconds
  • Latency: 200 milliseconds to first token
  • Base Throughput: 450 tokens/second
  • Effective Throughput: 441 tokens/second (temperature-adjusted)

Best Use Cases

Use Claude Sonnet 4.6 for natural-language clinical narrative generation and GPT-5.4 mini for structuredhigh-reliability data extraction.

Want this applied to YOUR actual stack?

This calculator shows the math for Claude Sonnet 4.6. Your decision needs more — current infrastructure, compliance requirements, actual workload patterns, volume tiers — that change which model is right for you.

Get a $39 personalized AI Architecture Audit. PDF tailored to your stack, delivered in under 60 seconds. 7-day no-questions-asked refund.

Get my instant AI audit — $39 →

GPT-5.4 mini OpenAI

$0.012563 (rounded ~ $0.01)
Total Cost
⚡ 50% Cached 📊 Batch API 🔧 Tools
👁️
Vision/Images
✓ Available
🎧
Audio Processing
✗ Not Available
🎥
Video Analysis
✗ Not Available
🔧
Tool Usage
✓ Available
📄
OCR Support
✗ Not Available
📊
Batch API
✓ Available
⚡
Caching
✓ Available
90% savings

💰 Total Cost Calculation (from Plugin)

Base Cost (No Optimizations) $0.021000 (rounded ~ $0.02) Input: $0.018750 (rounded ~ $0.02)
Output: $0.002250
Optimized Cost $0.012563 (rounded ~ $0.01) Input: $0.018750 (rounded ~ $0.02)
Output: $0.002250
Unit: $0.000000
Fees: $0.000000
Total Savings $0.008438 (rounded ~ $0.01) 40.2% discount

Advanced Cost Breakdown (from Plugin)

📊 Batch API
50.0% off
Asynchronous processing discount

Detailed Cost Analysis (from Plugin)

For 100,000 input tokens and 2,000 output tokens:

  • Input Cost: $0.018750 (rounded ~ $0.02)
  • Output Cost: $0.002250
  • Total Cost: $0.012563 (rounded ~ $0.01)
  • Cost per 1K tokens: $0.000123
  • Tokens per dollar: 8,119,403 tokens
  • Context Window: 400000 tokens

Speed & Performance Analysis

With a processing speed of 500 tokens per second and 180ms time to first token:

  • Processing Time: 3 minutes, 28.26 seconds
  • Latency: 180 milliseconds to first token
  • Base Throughput: 500 tokens/second
  • Effective Throughput: 490 tokens/second (temperature-adjusted)

Best Use Cases

Use Claude Sonnet 4.6 for natural-language clinical narrative generation and GPT-5.4 mini for structuredhigh-reliability data extraction.

Want this applied to YOUR actual stack?

This calculator shows the math for GPT-5.4 mini. Your decision needs more — current infrastructure, compliance requirements, actual workload patterns, volume tiers — that change which model is right for you.

Get a $39 personalized AI Architecture Audit. PDF tailored to your stack, delivered in under 60 seconds. 7-day no-questions-asked refund.

Get my instant AI audit — $39 →

✨ Market Recommendations AI Model Registry

← Back to Claude Sonnet 4.6
📋 Active Input Parameters
Input Tokens: 100,000
Output Tokens: 2,000
Batch API: Enabled (50% discount)
Cached Tokens: 50%
Tools: Enabled
Rank AI Model & Provider Total Cost vs Claude Sonnet 4.6 vs GPT-5.4 mini
🏆 Mistral Small 3
Mistral AI
 $0.001525 Best Value ↓ 96.9% cheaper ↓ 87.9% cheaper
🥈 Grok Code Fast 1
xAI
 $0.003500 ↓ 92.8% cheaper ↓ 72.1% cheaper
🥉 Gemini 3.1 Flash Lite
Google
 $0.004188 ↓ 91.4% cheaper ↓ 66.7% cheaper
#4 Gemini 2.5 Flash
Google
 $0.005375 (rounded ~ $0.01) ↓ 89% cheaper ↓ 57.2% cheaper
#5 Mistral Large 3
Mistral AI
 $0.007625 (rounded ~ $0.01) ↓ 84.4% cheaper ↓ 39.3% cheaper
#6 GPT-5.4 mini
OpenAI
 $0.012563 (rounded ~ $0.01) ↓ 74.2% cheaper Same price
#7 o4-mini Deep Research
OpenAI
 $0.015750 (rounded ~ $0.02) ↓ 67.7% cheaper ↑ 25.4% more
#8 Claude Haiku 4.5
Anthropic
 $0.016250 (rounded ~ $0.02) ↓ 66.7% cheaper ↑ 29.4% more
#9 Gemini 3.1 Flash
Google
 $0.016750 (rounded ~ $0.02) ↓ 65.6% cheaper ↑ 33.3% more
#10 o4-mini
OpenAI
 $0.017325 (rounded ~ $0.02) ↓ 64.5% cheaper ↑ 37.9% more
#11 Grok 4.3
xAI
 $0.018438 (rounded ~ $0.02) ↓ 62.2% cheaper ↑ 46.8% more
#12 Gemini 3.5 Flash
Google
 $0.025125 (rounded ~ $0.03) ↓ 48.5% cheaper ↑ 100% more
#13 Grok 4.20 Beta
xAI
 $0.030500 ↓ 37.4% cheaper ↑ 142.8% more
#14 GPT-5.3 Codex Spark
OpenAI
 $0.031063 (rounded ~ $0.03) ↓ 36.3% cheaper ↑ 147.3% more
#15 GPT-5.3 Instant
OpenAI
 $0.031063 (rounded ~ $0.03) ↓ 36.3% cheaper ↑ 147.3% more
#16 Gemini 2.5 Pro
Google
 $0.044375 (rounded ~ $0.04) ↓ 9% cheaper ↑ 253.2% more
#17 Gemini 3.1 Pro
Google
 $0.067000 (rounded ~ $0.07) ↑ 37.4% more ↑ 433.3% more
#18 Claude Opus 4.7
Anthropic
 $0.081250 (rounded ~ $0.08) ↑ 66.7% more ↑ 546.8% more
#19 Claude Opus 4.8
Anthropic
 $0.081250 (rounded ~ $0.08) ↑ 66.7% more ↑ 546.8% more
#20 Claude Opus 4.6
Anthropic
 $0.081250 (rounded ~ $0.08) ↑ 66.7% more ↑ 546.8% more
#21 GPT-5.4
OpenAI
 $0.083750 (rounded ~ $0.08) ↑ 71.8% more ↑ 566.7% more
#22 GPT-5.4 Thinking
OpenAI
 $0.083750 (rounded ~ $0.08) ↑ 71.8% more ↑ 566.7% more
#23 GPT-5.5 Instant
OpenAI
 $0.083750 (rounded ~ $0.08) ↑ 71.8% more ↑ 566.7% more
#24 o3 Deep Research
OpenAI
 $0.157500 (rounded ~ $0.16) ↑ 223.1% more ↑ 1153.7% more
#25 GPT-5.5
OpenAI
 $0.167500 (rounded ~ $0.17) ↑ 243.6% more ↑ 1233.3% more
#26 o3 Pro
OpenAI
 $0.315000 (rounded ~ $0.32) ↑ 546.2% more ↑ 2407.5% more
#27 GPT-5.2 Pro
OpenAI
 $0.372750 (rounded ~ $0.37) ↑ 664.6% more ↑ 2867.2% more
#28 GPT-5.2 Pro
OpenAI
 $0.372750 (rounded ~ $0.37) ↑ 664.6% more ↑ 2867.2% more
🏆

Mistral Small 3
Mistral AI

$0.001525
vs Claude Sonnet 4.6: ↓ 96.9%
vs GPT-5.4 mini: ↓ 87.9%
🥈

Grok Code Fast 1
xAI

$0.003500
vs Claude Sonnet 4.6: ↓ 92.8%
vs GPT-5.4 mini: ↓ 72.1%
🥉

Gemini 3.1 Flash Lite
Google

$0.004188
vs Claude Sonnet 4.6: ↓ 91.4%
vs GPT-5.4 mini: ↓ 66.7%
#4

Gemini 2.5 Flash
Google

$0.005375 (rounded ~ $0.01)
vs Claude Sonnet 4.6: ↓ 89%
vs GPT-5.4 mini: ↓ 57.2%
#5

Mistral Large 3
Mistral AI

$0.007625 (rounded ~ $0.01)
vs Claude Sonnet 4.6: ↓ 84.4%
vs GPT-5.4 mini: ↓ 39.3%
#6

GPT-5.4 mini
OpenAI

$0.012563 (rounded ~ $0.01)
vs Claude Sonnet 4.6: ↓ 74.2%
vs GPT-5.4 mini: Same
#7

o4-mini Deep Research
OpenAI

$0.015750 (rounded ~ $0.02)
vs Claude Sonnet 4.6: ↓ 67.7%
vs GPT-5.4 mini: ↑ 25.4%
#8

Claude Haiku 4.5
Anthropic

$0.016250 (rounded ~ $0.02)
vs Claude Sonnet 4.6: ↓ 66.7%
vs GPT-5.4 mini: ↑ 29.4%
#9

Gemini 3.1 Flash
Google

$0.016750 (rounded ~ $0.02)
vs Claude Sonnet 4.6: ↓ 65.6%
vs GPT-5.4 mini: ↑ 33.3%
#10

o4-mini
OpenAI

$0.017325 (rounded ~ $0.02)
vs Claude Sonnet 4.6: ↓ 64.5%
vs GPT-5.4 mini: ↑ 37.9%
#11

Grok 4.3
xAI

$0.018438 (rounded ~ $0.02)
vs Claude Sonnet 4.6: ↓ 62.2%
vs GPT-5.4 mini: ↑ 46.8%
#12

Gemini 3.5 Flash
Google

$0.025125 (rounded ~ $0.03)
vs Claude Sonnet 4.6: ↓ 48.5%
vs GPT-5.4 mini: ↑ 100%
#13

Grok 4.20 Beta
xAI

$0.030500
vs Claude Sonnet 4.6: ↓ 37.4%
vs GPT-5.4 mini: ↑ 142.8%
#14

GPT-5.3 Codex Spark
OpenAI

$0.031063 (rounded ~ $0.03)
vs Claude Sonnet 4.6: ↓ 36.3%
vs GPT-5.4 mini: ↑ 147.3%
#15

GPT-5.3 Instant
OpenAI

$0.031063 (rounded ~ $0.03)
vs Claude Sonnet 4.6: ↓ 36.3%
vs GPT-5.4 mini: ↑ 147.3%
#16

Gemini 2.5 Pro
Google

$0.044375 (rounded ~ $0.04)
vs Claude Sonnet 4.6: ↓ 9%
vs GPT-5.4 mini: ↑ 253.2%
#17

Gemini 3.1 Pro
Google

$0.067000 (rounded ~ $0.07)
vs Claude Sonnet 4.6: ↑ 37.4%
vs GPT-5.4 mini: ↑ 433.3%
#18

Claude Opus 4.7
Anthropic

$0.081250 (rounded ~ $0.08)
vs Claude Sonnet 4.6: ↑ 66.7%
vs GPT-5.4 mini: ↑ 546.8%
#19

Claude Opus 4.8
Anthropic

$0.081250 (rounded ~ $0.08)
vs Claude Sonnet 4.6: ↑ 66.7%
vs GPT-5.4 mini: ↑ 546.8%
#20

Claude Opus 4.6
Anthropic

$0.081250 (rounded ~ $0.08)
vs Claude Sonnet 4.6: ↑ 66.7%
vs GPT-5.4 mini: ↑ 546.8%
#21

GPT-5.4
OpenAI

$0.083750 (rounded ~ $0.08)
vs Claude Sonnet 4.6: ↑ 71.8%
vs GPT-5.4 mini: ↑ 566.7%
#22

GPT-5.4 Thinking
OpenAI

$0.083750 (rounded ~ $0.08)
vs Claude Sonnet 4.6: ↑ 71.8%
vs GPT-5.4 mini: ↑ 566.7%
#23

GPT-5.5 Instant
OpenAI

$0.083750 (rounded ~ $0.08)
vs Claude Sonnet 4.6: ↑ 71.8%
vs GPT-5.4 mini: ↑ 566.7%
#24

o3 Deep Research
OpenAI

$0.157500 (rounded ~ $0.16)
vs Claude Sonnet 4.6: ↑ 223.1%
vs GPT-5.4 mini: ↑ 1153.7%
#25

GPT-5.5
OpenAI

$0.167500 (rounded ~ $0.17)
vs Claude Sonnet 4.6: ↑ 243.6%
vs GPT-5.4 mini: ↑ 1233.3%
#26

o3 Pro
OpenAI

$0.315000 (rounded ~ $0.32)
vs Claude Sonnet 4.6: ↑ 546.2%
vs GPT-5.4 mini: ↑ 2407.5%
#27

GPT-5.2 Pro
OpenAI

$0.372750 (rounded ~ $0.37)
vs Claude Sonnet 4.6: ↑ 664.6%
vs GPT-5.4 mini: ↑ 2867.2%
#28

GPT-5.2 Pro
OpenAI

$0.372750 (rounded ~ $0.37)
vs Claude Sonnet 4.6: ↑ 664.6%
vs GPT-5.4 mini: ↑ 2867.2%
✨ How recommendations work (v8.6.0): We scan all active models in the registry and only include those that support ALL your current inputs. For token-based models, we check if they can handle your token counts. For special pricing models (OCR, video, audio), we verify they have the correct pricing structure. Features marked requested were in your inputs but not supported by that model. Now using official provider pricing without reseller markups.

Clinical Note Generation Workflows

For high-volume clinical note generation, the choice between Claude Sonnet 4.6 and GPT-5.4 mini hinges on the balance between narrative quality and structural rigidity. In healthcare settings, documentation often serves two masters: the clinician who needs a readable, natural-language narrative, and the billing department that requires strictly formatted codes and structured data fields.

Claude Sonnet 4.6 excels when the priority is narrative cohesion and medical reasoning. Its ability to maintain a consistent tone across long, complex consultation transcripts makes it the preferred choice for generating detailed SOAP (Subjective, Objective, Assessment, Plan) notes that clinicians feel comfortable signing off on without heavy manual editing. It produces prose that naturally bridges different segments of a patient interaction.

GPT-5.4 mini, conversely, is an architectural powerhouse for data-dense extraction. If your primary goal is to turn unstructured doctor-patient conversations into JSON-ready diagnosis codes, medication lists, and follow-up flags, its performance with function calling and structured outputs is difficult to beat. It minimizes the risk of format-related errors, ensuring that the downstream EHR integration receives exactly the fields it expects.

For enterprise-scale deployments at the 100K-token per-call level, evaluate your workflow’s primary friction point. If the bottleneck is clinician time spent re-writing the draft, leverage Claude. If the bottleneck is pipeline failures due to malformed data, prioritize the structured reliability of GPT-5.4 mini.

Frequently Asked Questions

How accurate are these AI model cost calculations?
Our calculations are based on official pricing from each provider (Google, OpenAI, Anthropic, Meta, xAI, Perplexity, DeepSeek, Mistral) and are updated regularly. We account for all factors including multimodal inputs, caching discounts, batch API pricing, tool usage multipliers, OCR processing, audio minutes, silence fees, and research mode pricing. Note: Reseller markups and dedicated instance multipliers have been removed to reflect official provider pricing.
How does prompt caching work?
Caching discounts vary by provider: Google and OpenAI offer 90% discounts on cached input tokens. Anthropic uses write (1.25x) and read (0.10x) multipliers. Savings are applied to the token portion only, not unit-based fees.
How do Market Recommendations work (v8.6.0)?
Our recommendation engine scans the entire model registry and only includes models that support ALL your current input parameters (tokens, images, video, audio, OCR, tools, batch API, etc.). It calculates exact costs with your settings and sorts by price, showing you the best value options that can handle your complete workflow. Special pricing models (OCR, video, audio, image generation) are properly handled and only appear when their specific input types are requested. v8.6.0 removes reseller markups (20% buffer) and dedicated instance multipliers to reflect official provider pricing.
What is the YemHub AI Calculator Tool?
The YemHub AI Calculator is the most comprehensive tool for estimating costs and comparing performance metrics across 50+ AI models. It calculates token-based pricing, analyzes multimodal processing, accounts for state-dependent pricing (context cliffs, tiered tunnels), provides optimization recommendations, and now offers intelligent market matching to find the best alternatives for your specific needs.