Clinical Note Generation: Cost for 5M Tokens Monthly with o3 Pro vs Claude Sonnet 4.6

Claude Sonnet 4.6 has been replaced by Claude Sonnet 5

The pricing shown below is for the older model and is kept for reference. If you are choosing a model today, use the current version — its rate and context window differ.

See current Claude Sonnet 5 pricing →  ·  All recent pricing changes

o3 Pro vs Claude Sonnet 4.6
Complete Comparison: 5,000,000 input tokens × 1,000 output tokens
Comparison Mode
⚡ 20% Cached

Complete comparison of pricing, performance, and capabilities for 2 leading AI models with 20% Cached.

⚡ Caching Optimized (up to 90% savings) 📊 Batch API
Comparison Criteria o3 Pro
OpenAI
Claude Sonnet 4.6
Anthropic
Calculation Results (Current Inputs) (20% cached)
Input Tokens 5,000,000 5,000,000
Output Tokens 1,000 1,000
Cost Breakdown
Input Cost $25.000000Worst $3.750000Best
Output Cost $0.020000Worst $0.003750Best
Unit Cost (Audio/OCR) $0.000000 $0.000000
Service Fees $0.000000 $0.000000
Total Cost $20.520000 Most Expensive $3.078750 (rounded ~ $3.08) Best Value
Processing Time 4 hours, 2 minutes, 54.52 seconds Slowest 3 hours, 8 minutes, 55.78 seconds Fastest
Tokens per Second 350Slowest 450Fastest
Time to First Token 300ms Worst 200ms Best
Cost per 1K tokens $0.004103Worst $0.000616Best
Tokens per Dollar 243,713Worst Value 1,624,361Best Value
Cost per 1 Million Tokens (Informational)
Input Cost / 1M (Base) $5.000000Worst $0.750000Best
Output Cost / 1M (Base) $20.000000Worst $3.750000Best
Input Cost / 1M (Optimized) $2.500000Worst
Optimizations: 50.0% batch
$0.375000 (rounded ~ $0.38)Best
Optimizations: 50.0% batch
Output Cost / 1M (Optimized) $10.000000Worst
Optimizations: 50.0% batch
$1.875000 (rounded ~ $1.88)Best
Optimizations: 50.0% batch
Capabilities & Advanced Features
Images Support ✓ Supported ✓ Supported
Caching Support
20
✓ Supported ✓ Supported
Batch API Support ✓ Supported ✓ Supported
Tool Usage Support ✓ Supported ✓ Supported
Scroll horizontally to see all data

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ℹ️ Bulk Calculation: Total volume exceeds single-request limit of 200,000 tokens. Budgeting mode active.

Select AI Model

o3 Pro
OpenAIMax Context: 200,000 tokens
$20 / $80 per 1M tokens
Use Batch API (50% discount)
20%
Provider-specific multipliers applied after all calculations
Enable for cache discounts
Select platform to enforce context limits
Number of requests (max 1M). Summary view auto-enabled >10k.

Calculate Token Costs

$20.000000 Input Cost
$0.020000 Output Cost
$0.000000 Unit Cost
$0.000000 Search Cost
$0.000000 Request Fee
$0.000000 Tool Fee
$0.000000 Code Execution
5,001,000Total Tokens
$0.004103Cost per 1K
243,713Tokens per $
📊 Advanced Cost Breakdown

Processing Speed

242m 54s Processing Time
350 Tokens/Second
300ms Time to First Token
343 Effective Speed

Model Comparison

Select a model to see comparisons with competitors.

Model Information

Select a model to see detailed information.

🔄 Advanced Options

⚡ Optimization
Flat fee per session (e.g., $0.03 for Code Interpreter)
Hourly storage fee for cached data
First 50 hours free, $0.05/hour after

🧠 Reasoning & Thinking
Manual thinking tokens (billed at output rate)

🔧 Special Modes
Enable 6.0x Fast Mode multiplier

📚 Research & Citations
Enable $1.00/$4.00 rates + $10.00/1k search
Enable research tier pricing
Fee per source cited

🎤 Realtime Audio & Video
Session length for billing
📊 Multiple Models Detected: This page contains data for 2 models. See the detailed comparison table above, and switch between models using tabs below.

o3 Pro OpenAI

$20.520000
Total Cost
⚠️ Bulk Calculation: Total volume exceeds single-request limit of 200,000 tokens. Budgeting mode active.
⚡ 20% Cached 📊 Batch API 🔧 Tools
👁️
Vision/Images
✓ Available
🎧
Audio Processing
✗ Not Available
🎥
Video Analysis
✗ Not Available
🔧
Tool Usage
✓ Available
📄
OCR Support
✗ Not Available
📊
Batch API
✓ Available
Caching
✓ Available
90% savings

💰 Total Cost Calculation (from Plugin)

Base Cost (No Optimizations) $25.020000 Input: $25.000000
Output: $0.020000
Optimized Cost $20.520000 Input: $25.000000
Output: $0.020000
Unit: $0.000000
Fees: $0.000000
Total Savings $4.500000 18.0% discount

Advanced Cost Breakdown (from Plugin)

📊 Batch API
50.0% off
Asynchronous processing discount

Detailed Cost Analysis (from Plugin)

For 5,000,000 input tokens and 1,000 output tokens:

  • Input Cost: $25.000000
  • Output Cost: $0.020000
  • Total Cost: $20.520000
  • Cost per 1K tokens: $0.004103
  • Tokens per dollar: 243,713 tokens
  • Context Window: 200000 tokens

Speed & Performance Analysis

With a processing speed of 350 tokens per second and 300ms time to first token:

  • Processing Time: 4 hours, 2 minutes, 54.52 seconds
  • Latency: 300 milliseconds to first token
  • Base Throughput: 350 tokens/second
  • Effective Throughput: 343 tokens/second (temperature-adjusted)

Best Use Cases

Use o3 Pro for complex diagnostic reasoning and Claude Sonnet 4.6 for reliablehigh-throughput structured clinical data extraction.

Want this applied to YOUR actual stack?

This calculator shows the math for o3 Pro. Your decision needs more — current infrastructure, compliance requirements, actual workload patterns, volume tiers — that change which model is right for you.

Get a $39 personalized AI Architecture Audit. PDF tailored to your stack, delivered in under 60 seconds. 7-day no-questions-asked refund.

Get my instant AI audit — $39 →

Claude Sonnet 4.6 Anthropic 1000000

$3.078750 (rounded ~ $3.08)
Total Cost
⚠️ Bulk Calculation: Total volume exceeds single-request limit of 1,000,000 tokens. Budgeting mode active.
⚡ 20% Cached 📊 Batch API 🔧 Tools
👁️
Vision/Images
✓ Available
🎧
Audio Processing
✗ Not Available
🎥
Video Analysis
✗ Not Available
🔧
Tool Usage
✓ Available
📄
OCR Support
✗ Not Available
📊
Batch API
✓ Available
Caching
✓ Available
90% savings

💰 Total Cost Calculation (from Plugin)

Base Cost (No Optimizations) $3.753750 (rounded ~ $3.75) Input: $3.750000
Output: $0.003750
Optimized Cost $3.078750 (rounded ~ $3.08) Input: $3.750000
Output: $0.003750
Unit: $0.000000
Fees: $0.000000
Total Savings $0.675000 (rounded ~ $0.68) 18.0% discount

Advanced Cost Breakdown (from Plugin)

📊 Batch API
50.0% off
Asynchronous processing discount

Detailed Cost Analysis (from Plugin)

For 5,000,000 input tokens and 1,000 output tokens:

  • Input Cost: $3.750000
  • Output Cost: $0.003750
  • Total Cost: $3.078750 (rounded ~ $3.08)
  • Cost per 1K tokens: $0.000616
  • Tokens per dollar: 1,624,361 tokens
  • Context Window: 1000000 tokens

Speed & Performance Analysis

With a processing speed of 450 tokens per second and 200ms time to first token:

  • Processing Time: 3 hours, 8 minutes, 55.78 seconds
  • Latency: 200 milliseconds to first token
  • Base Throughput: 450 tokens/second
  • Effective Throughput: 441 tokens/second (temperature-adjusted)

Best Use Cases

Use o3 Pro for complex diagnostic reasoning and Claude Sonnet 4.6 for reliablehigh-throughput structured clinical data extraction.

Want this applied to YOUR actual stack?

This calculator shows the math for Claude Sonnet 4.6. Your decision needs more — current infrastructure, compliance requirements, actual workload patterns, volume tiers — that change which model is right for you.

Get a $39 personalized AI Architecture Audit. PDF tailored to your stack, delivered in under 60 seconds. 7-day no-questions-asked refund.

Get my instant AI audit — $39 →

✨ Market Recommendations AI Model Registry

← Back to o3 Pro
📋 Active Input Parameters
Input Tokens: 5,000,000
Output Tokens: 1,000
Batch API: Enabled (50% discount)
Cached Tokens: 20%
Tools: Enabled
🔍
No Alternatives Found
No other models in the registry support all your current input parameters. Try adjusting some parameters to see more options.
Remove Images Remove Video Remove Audio Remove OCR Remove Tools
✨ How recommendations work (v8.6.0): We scan all active models in the registry and only include those that support ALL your current inputs. For token-based models, we check if they can handle your token counts. For special pricing models (OCR, video, audio), we verify they have the correct pricing structure. Features marked requested were in your inputs but not supported by that model. Now using official provider pricing without reseller markups.

Clinical Note Generation at Scale

For mid-market healthcare SaaS platforms, transforming doctor-dictated audio or raw transcripts into formalized clinical records is a high-stakes balancing act. The requirement is not just speed; it is clinical accuracy, strict adherence to structured schema, and the ability to handle complex diagnostic logic without hallucination. As you scale to 5M tokens monthly, the choice between reasoning-heavy models and instruction-following powerhouses becomes a primary driver of your unit economics and product reliability.

Strategic Model Selection

o3 Pro is purpose-built for deep reasoning. In clinical contexts, this model excels where diagnostic validation, contradictory evidence detection, and multi-step clinical logic are required. If your product involves automated differential diagnosis support or complex summarization that requires ‘thinking’ through patient histories, o3 Pro provides a safety-first approach to reasoning.

Claude Sonnet 4.6, by contrast, is frequently the preferred choice for high-volume structured data extraction. Its ability to follow complex formatting instructions—such as mapping clinical notes directly to FHIR resources or specific EHR JSON schemas—is industry-leading. For standard clinical note generation where the primary task is parsing and formatting, Claude often achieves higher throughput and lower latency, making it ideal for standardizing the millions of tokens your pipeline processes monthly.

Reducing Vendor Lock-in

Given the regulatory sensitivity of clinical data, relying on a single provider introduces operational risk. A robust architecture often employs both models: using Claude Sonnet 4.6 for routine extraction and o3 Pro as a ‘reasoning layer’ for complex cases requiring high-fidelity verification.

Frequently Asked Questions

How accurate are these AI model cost calculations?
Our calculations are based on official pricing from each provider (Google, OpenAI, Anthropic, Meta, xAI, Perplexity, DeepSeek, Mistral) and are updated regularly. We account for all factors including multimodal inputs, caching discounts, batch API pricing, tool usage multipliers, OCR processing, audio minutes, silence fees, and research mode pricing. Note: Reseller markups and dedicated instance multipliers have been removed to reflect official provider pricing.
How does prompt caching work?
Caching discounts vary by provider: Google and OpenAI offer 90% discounts on cached input tokens. Anthropic uses write (1.25x) and read (0.10x) multipliers. Savings are applied to the token portion only, not unit-based fees.
How do Market Recommendations work (v8.6.0)?
Our recommendation engine scans the entire model registry and only includes models that support ALL your current input parameters (tokens, images, video, audio, OCR, tools, batch API, etc.). It calculates exact costs with your settings and sorts by price, showing you the best value options that can handle your complete workflow. Special pricing models (OCR, video, audio, image generation) are properly handled and only appear when their specific input types are requested. v8.6.0 removes reseller markups (20% buffer) and dedicated instance multipliers to reflect official provider pricing.
What is the YemHub AI Calculator Tool?
The YemHub AI Calculator is the most comprehensive tool for estimating costs and comparing performance metrics across 50+ AI models. It calculates token-based pricing, analyzes multimodal processing, accounts for state-dependent pricing (context cliffs, tiered tunnels), provides optimization recommendations, and now offers intelligent market matching to find the best alternatives for your specific needs.